PYRAZOLO AND TRIAZOLO BICYCLIC COMPOUNDS AS JAK KINASE INHIBITORS

The invention provides compounds of formula (I):or a pharmaceutically-acceptable salt thereof, wherein the variables are defined in the specification, that are inhibitors of JAK kinases, particularly JAK3. The invention also provides crystalline forms, pharmaceutical compositions comprising such com...

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Bibliographic Details
Main Authors WANG, Diana Jin, LOO, Mandy, RAPTA, Miroslav, LAM, Tom M, PALERMO, Anthony Francesco, FENSTER, Erik, MCKINNELL, Robert Murray, NZEREM, Jerry, DABROS, Marta, THALLADI, Venkat R, FRAGA, Breena
Format Patent
LanguageEnglish
Published 28.04.2022
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Summary:The invention provides compounds of formula (I):or a pharmaceutically-acceptable salt thereof, wherein the variables are defined in the specification, that are inhibitors of JAK kinases, particularly JAK3. The invention also provides crystalline forms, pharmaceutical compositions comprising such compounds, methods of using such compounds to treat gastrointestinal and other inflammatory diseases, and processes and intermediates useful for preparing such compounds.
Bibliography:Application Number: ZA20200000561