PYRIDIN-2(1H)-ONE QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS

The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: (I) where A, U, W1, W2, W3, R1-R6, and R9 are described herein.

Saved in:
Bibliographic Details
Main Authors JUSTIN A CARAVELLA, JIAN LIN, ANNA ERICSSON, R BRUCE DIEBOLD, SUSAN ASHWELL, WEI LU, ZHONGGUO WANG, GARY GUSTAFSON, ANN-MARIE CAMPBELL, DAVID R LANCIA JR
Format Patent
LanguageEnglish
Published 20.12.2023
Online AccessGet full text

Cover

More Information
Summary:The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: (I) where A, U, W1, W2, W3, R1-R6, and R9 are described herein.
Bibliography:Application Number: ZA20190002446