MODIFIED GAMMA DELTA CELLS AND USES THEREOF
The present invention provides composition and methods for the treatment of cancer or infectious diseases in a human. The invention includes the generation and administration of gamma delta T cells that express chimeric antigen receptors (CARs) comprising an antigen binding domain, a hinge domain, a...
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| Main Authors | , , , |
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| Format | Patent |
| Language | English |
| Published |
28.06.2023
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| Online Access | Get full text |
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| Abstract | The present invention provides composition and methods for the treatment of cancer or infectious diseases in a human. The invention includes the generation and administration of gamma delta T cells that express chimeric antigen receptors (CARs) comprising an antigen binding domain, a hinge domain, a transmembrane domain, a costimulatory signalling domain with the inclusion or not of a CD3 zeta signalling domain. Expression of CAR sequence omitting the CD3 zeta signalling domain in gamma delta T cells, provides for a CAR-T therapy in vivo, which will effect cytolysis only on target cells providing ligands for activation of the gamma delta T cell receptor (TCR). |
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| AbstractList | The present invention provides composition and methods for the treatment of cancer or infectious diseases in a human. The invention includes the generation and administration of gamma delta T cells that express chimeric antigen receptors (CARs) comprising an antigen binding domain, a hinge domain, a transmembrane domain, a costimulatory signalling domain with the inclusion or not of a CD3 zeta signalling domain. Expression of CAR sequence omitting the CD3 zeta signalling domain in gamma delta T cells, provides for a CAR-T therapy in vivo, which will effect cytolysis only on target cells providing ligands for activation of the gamma delta T cell receptor (TCR). |
| Author | DARIA PARUZINA MICHAEL DAVID LEEK ADELE HANNIGAN AGAPITOS PATAKAS |
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| Snippet | The present invention provides composition and methods for the treatment of cancer or infectious diseases in a human. The invention includes the generation and... |
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| Title | MODIFIED GAMMA DELTA CELLS AND USES THEREOF |
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