MODIFIED GAMMA DELTA CELLS AND USES THEREOF

The present invention provides composition and methods for the treatment of cancer or infectious diseases in a human. The invention includes the generation and administration of gamma delta T cells that express chimeric antigen receptors (CARs) comprising an antigen binding domain, a hinge domain, a...

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Bibliographic Details
Main Authors DARIA PARUZINA, ADELE HANNIGAN, AGAPITOS PATAKAS, MICHAEL DAVID LEEK
Format Patent
LanguageEnglish
Published 28.06.2023
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Summary:The present invention provides composition and methods for the treatment of cancer or infectious diseases in a human. The invention includes the generation and administration of gamma delta T cells that express chimeric antigen receptors (CARs) comprising an antigen binding domain, a hinge domain, a transmembrane domain, a costimulatory signalling domain with the inclusion or not of a CD3 zeta signalling domain. Expression of CAR sequence omitting the CD3 zeta signalling domain in gamma delta T cells, provides for a CAR-T therapy in vivo, which will effect cytolysis only on target cells providing ligands for activation of the gamma delta T cell receptor (TCR).
Bibliography:Application Number: ZA20170006922