DIAZOLE LACTAMS

Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are diazole lactam derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated disease, and as controls in assays for the i...

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Main Authors XI CHEN, PINGCHEN FAN, YANDONG LI, DEAN DRAGOLI, JAY P POWERS, PENGLIE ZHANG, SREENIVAS PUNNA, HIROKO TANAKA, VIENGKHAM MALATHONG
Format Patent
LanguageEnglish
Published 25.09.2019
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Summary:Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are diazole lactam derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated disease, and as controls in assays for the identification of competitive CCR1 antagonists.
Bibliography:Application Number: ZA20150004122