PYRIDONE AND AZA-PYRIDONE COMPOUNDS AND METHODS OF USE

Pyridone and aza-pyridone compounds of Formula I are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I f...

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Main Authors KROPF JEFFREY E, KRISHNAMOORTHY RAVI, LEE SEUNG H, ZHAO ZHONGDONG, BARBOSA ANTONIO J.M, MITCHELL SCOTT A, YOUNG WENDY, ORTWINE DANIEL, SCHMITT AARON C, CURRIE KEVIN S, XU JIANJUN, ZHICHKIN PAVEL E, ZHANG HONGHU, WANG XIAOJING, BLOMGREN PETER A
Format Patent
LanguageEnglish
Published 28.08.2013
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Pyridone and aza-pyridone compounds of Formula I are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
Bibliography:Application Number: ZA20120009205