STABILIZED LIPID FORMULATION OF APOPTOSIS PROMOTER

An orally deliverable pharmaceutical composition comprises a Bcl-2 family protein inhibitory compound, e.g., ABT-263, a heavier-chalcogen antioxidant and a substantially non-aqueous lipid carrier, wherein said compound and said antioxidant are in solution in the carrier. The composition is suitable...

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Main Authors CATRON NATHANIEL, FISCHER CRISTINA, FICKES MICHAEL, HEEMSTRA KATHERINE, SCHMITT ERIC, SANZGIRI YESHWANT, TONG PING, ZHANG GEOFF, HAIGHT ANTHONY R, ZHOU DELIANG
Format Patent
LanguageEnglish
Published 26.03.2014
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:An orally deliverable pharmaceutical composition comprises a Bcl-2 family protein inhibitory compound, e.g., ABT-263, a heavier-chalcogen antioxidant and a substantially non-aqueous lipid carrier, wherein said compound and said antioxidant are in solution in the carrier. The composition is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.
Bibliography:Application Number: ZA20110007594