PHARMACEUTICAL COMPOSITION UTILISING COMBINATIONS OF VARIANTS OF THE GONADOTROPIN-LIBERATING HORMANE (GNRH) AS IMMUNOGEN

• Main Authors: BASULTO BAKER ROBERTO, AGUERO BARROCAL LUIS ALBERTO, GUILLEN NIETO GERARDO ENRIQUE, REYES ACOSTA OSVALDO, CASTRO SANTANA MARIA, FUENTES AGUILAR FRANKLIN, LOPEZ SAEZ YOVISLEIDYS, GARAY PEREZ HILDA ELISA, CALZADA AGUILERA LESVIA, JUNCO BARRANCO JESUS ARTURO, PIMENTEL VAZQUEZ EULOGIO, ARTEAGA MORE NIURKA ONEYSI, BOVER FUENTES EDDY EMILIO
• Format: Patent
• Language: English
• Published: 25.01.2012
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

A pharmaceutical composition using natural gonadotropin - releasing hormone (GnRH), and/or some of its mimetic peptides, indistinctly bound by its amino or carboxyl extremes to a carrier molecule; in one case by its carboxyl extreme and in the other case by the amino terminal extreme, thus eliciting a faster and more potent immunological response against the endogenous GnRH hormone. This finally leads to the ablation of the GnRH and consequently of the rest of the involved hormones in the stream GnRH/LH-FSH/Testosterone-(estrogens). An advantage of this formulation consists on facilitating the exposition to the immune system of a greater number of epitopes of the GnRH or its mimetics, minimizing thus the steric hindrance produced by the carriers. This invention has a direct application in the castration of pets and animals of economic interest, in the control of human fertility as well as in the treatment of hormone-sensitive tumors, such as that of the prostate, the breast, ovary, the endometry, testicles, hypophysis, salivary glands and other kinds of human tumors.