BICYCLIC NITROIMIDAZOLES COVALENTLLY LINKED TO SUBSTITUTED PHENYL OXAZOLIDINONES

The current invention provides a series of bicyclic nitroimidazole-substituted phenyl oxazolidinones in which a bicyclic nitroimidazole pharmacophore is covalently bonded to a phenyl oxazolidinone, their pharmaceutical compositions, and the method of use of the compositions for prevention and treatm...

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Main Authors SUTHERLAND HAMISH SCOTT, PALMER BRIAN DESMOND, CHEN DIANJUN D, BLASER ANDRIAN, MA ZHENKUN, THOMPSON ANDREW M, DENNY WILLIAM ALEXANDER, SONG MINSOO, LU GENLIANG, DING CHARLES Z, KMENTOVA IVETA, COMBRINK KEITH, WANG JIANCHENG
Format Patent
LanguageEnglish
Published 29.06.2011
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Summary:The current invention provides a series of bicyclic nitroimidazole-substituted phenyl oxazolidinones in which a bicyclic nitroimidazole pharmacophore is covalently bonded to a phenyl oxazolidinone, their pharmaceutical compositions, and the method of use of the compositions for prevention and treatment of bacterial infections. The bicyclic nitroimidazole-substituted phenyl oxazolidinones possess surprising antibacterial activity against wild-type and resistant strains of pathogens, and are therefore useful for the prevention, control and treatment of a number of human and veterinary bacterial infections caused by these pathogens, such as Mycobacterium tuberculosis.
Bibliography:Application Number: ZA20100006824