PTRROLOPYRAZINE KINASE INHIBITORS

The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q and R are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.

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Bibliographic Details
Main Authors HENDRICKS ROBERT THAN, LOU YAN, PARK JAEHYEON, SMITH DAVID BERNARD, ELWORTHY TODD RICHARD, KONDRU RAMA K, SOTH MICHAEL, DU BOIS DAISY JOE, OWENS TIMOTHY D, HERMANN JOHANNES CORNELIUS
Format Patent
LanguageEnglish
Published 28.12.2011
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q and R are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
Bibliography:Application Number: ZA20100004942