CALICHEAMICIN DERIVATIVE-CARRIER CONJUGATES

Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with dicreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the...

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Main Authors KUNZ ARTHUR, MERCHANT NISHITH, RUBINO JOSEPH THOMAS, SIMPSON JOHN MCLEAN, POPPLEWELL ANDREW GEORGE, JAIN NEERA, ROBBINS PAUL DAVID, DAMLE NITIN KRISHNAJI, MORAN JUSTIN KEITH, RUPPEN MARK EDWARD, VIDUNAS EUGENE JOSEPH, DIJOSEPH JOHN FRANCIS
Format Patent
LanguageEnglish
Published 18.12.2019
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with dicreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
Bibliography:Application Number: ZA20100003874