PHARMACEUTICAL COMPOSITIONS CONTAINING THE ENZYME CYPROSIN,AN ASPARTIC PEPTIDASE FROM CYNARA CARDUNCULUS AND ITS INCLUSION IN ANTITUMOUR FORMULATIONS

An aspect of the present invention is the use of a preparation containing a phytepsin, more specifically a cyprosin, containing the heterodimer, its N-terminal pro-peptide, the mature N-terminal peptide, and mature C-terminal peptide, as well as other precursor species, processing products, and aggr...

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Main Authors SOARES DA CRUZ HELDER JOAQUIM, SOARES PAIS MARIA SALOME, DE SOUSA SAMPAIO PEDRO NUNO, SILVA SANTOS JORGE MIGUEL, BAPTISTA COELHO MARIA CONSTANCA, GANCHAS SOARES RITA ISABEL, DA CRUZ PEDRO ESTILITA
Format Patent
LanguageEnglish
Published 25.05.2011
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Summary:An aspect of the present invention is the use of a preparation containing a phytepsin, more specifically a cyprosin, containing the heterodimer, its N-terminal pro-peptide, the mature N-terminal peptide, and mature C-terminal peptide, as well as other precursor species, processing products, and aggregate species, either isolated or in any combinations of the former, native, extracted and partially purified from flowers of Cynara cardunculus, or recombinant, extracted from the supernatant from a culture of Saccharomyces cereviseae genetically modified for the heterologous production of cyprosin, for therapeutic applications more precisely for its use as an antitumor agent.
Bibliography:Application Number: ZA20100002086