INHIBITORS OF PROTEIN TYROSINE KINASE ACTIVITY

This invention relates to compounds that inhibit protein tyrosine kinase activity. In particular the invention relates to compounds that inhibit the protein tyrosine kinase activity of growth factor receptors, resulting in the inhibition of receptor signaling, for example, the inhibition of VEGF rec...

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Main Authors ISAKOVIC LJUBOMIR, VAISBURG ARKADII, GAUDETTE FREDERIC, CLARIDGE STEPHEN WILLIAM, ZHAN LIJIE, SAAVEDRA OSCAR MARIO, DEZIEL ROBERT, MANNION MICHAEL, ZHOU NANCY Z, UNO TETSUYUKI, RAEPPEL STEPHANE, RAEPPEL FRANCK
Format Patent
LanguageEnglish
Published 24.11.2010
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:This invention relates to compounds that inhibit protein tyrosine kinase activity. In particular the invention relates to compounds that inhibit the protein tyrosine kinase activity of growth factor receptors, resulting in the inhibition of receptor signaling, for example, the inhibition of VEGF receptor signaling and HGF receptor signaling. More particularly, the invention relates to compounds, compositions and methods for the inhibition of VEGF receptor signaling and HGF receptor signaling. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.
Bibliography:Application Number: ZA20100001512