Novel gene disruptions, compositions and methods relating thereto

• Main Authors: IRVING, BRYAN, SPARKS, MARY JEAN, SEVAUX, TRACY ELLEN WILLIS, RANGEL, CAROLINA, FAN, LIANGFEN, MINZE, LAURIE JEANETTE, SHI, ZHENG-ZHENG, MCLAIN, DINA REBECCA, MONTGOMERY, CHARLES A, VOGEL, PETER, COMBS, KATHERIN E, TOWNSEND, TERESA GAIL, STALA, JOY ANNE, PHILLIPS, HEIDI, HORNER, ALLISON ANNE BYERS, PAYNE, BOBBY JOE, FILVAROFF, ELLEN, DESAUVAGE, FREDERIC, JUNUTULA, JAGATH REDDY, MASSEY, ERIN MARIE
• Format: Patent
• Language: English
• Published: 31.03.2010
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; NEW BREEDS OF ANIMALS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; TRAPPING

The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO218, PRO228, PRO271, PRO273, PRO295, PRO302, PRO305, PRO326, PRO386, PRO655, PRO162, PRO788, PRO792, PRO940, PRO941, PRO1004, PRO1012, PRO1016, PRO474, PRO5238, PRO1069 PRO1111, PRO1113, PRO1130, PRO1195, PRO1271, PRO1865, PRO1879, PRO3446, PRO3543, PRO4329, PRO4352, PRO5733, PRO9859, PRO9864, PRO9904, PRO9907, PRO10013, PRO90948, PRO28694, PRO16089, PRO19563, PRO19675, PRO20084, PRO21434, PRO50332, PRO38465 or PRO346 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.