Cyclohexylpyrazole-lactam derivatives as inhibitors of 11-Beta-hydroxysteroid dehydrogenase 1

The present invention discloses novel compounds of Formula (I): having 11 -HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I), as well as methods of using the...

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Main Authors WALLACE, OWEN BRENDAN, WINNEROSKI, LEONARD LARRY JR, XU, YANPING, SNYDER, NANCY JUNE, ANZEVENO, PETER BIAGIO, SAEED, ASHRAF, MABRY, THOMAS EDWARD, AICHER, THOMAS DANIEL, LI, RENHUA, STEPHENSON, GREGORY ALAN, KRASUTSKY, ALEXEI PAVLOVYCH, TIAN, HONGQI
Format Patent
LanguageEnglish
Published 30.12.2009
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention discloses novel compounds of Formula (I): having 11 -HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I), as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, and other conditions associated with 11 -HSD type 1 activity.
Bibliography:Application Number: ZA20080008686