Diarylether derivatives as antitumor agents

• Main Authors: KOJIMA, YUTAKA, TAKASU, HIDEKI, HIGUCHI, KUMI, KAN, KEIZO, NAKAGAWA, TAKASHI, MIYAJIMA, KEISUKE, YASUMURA, KOICHI, YAMADA, SATOSHI, OHNISHI, KENJI, OTSUJI, SHU, MOTOYAMA, MASAAKI, KODAMA, TAKESHI, MATSUYAMA, HIRONORI, SUMIDA, TAKUMI, SAKAMOTO, MAKOTO
• Format: Patent
• Language: English
• Published: 25.11.2009
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

An object of the present invention is to provide a medicinal drug much improved in anti tumor activity and excellent in safety. According to the present invention, there is provided a medicinal drug containing a compound represented by the following general formula (1) or a salt thereof as an active ingredient: [Formula 1] wherein X1 represents a nitrogen atom or a group -CH , R1 represents a group -Z-R6, in which Z represents a group -CO-, a group -CH(OH)- or the like, R6 represents a 5- to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R2 represents a hydrogen atom or a halogen atom, Y represents a group -O-, a group -CO-, a group -CH(OH)- or a lower alkylene group, and A represents [Formula 2] wherein R3 represents a hydrogen atom, a lower alkoxy group or the like, p represents 1 or 2, R4 represents an imidazolyl lower alkyl group or the like.