Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade

• Main Authors: GARY W. FRANKLIN, JOHN J. PARLOW, MELVIN L. RUEPPEL, HORNGIH HUANG, RHONDA WOOD, CURRIE KUSTURIN, RICK FENTON, CHINGNG WANG, QINGPING ZENG, BRENDA CASE, DAVID B. REITZ, WILLIAM L. NEUMANN, MATTHEWS W. MAHONEY, MICHAEL S. SOUTH, MICHAEL J. HAYES, WEI HUANG, SCOTT A. LONG, TOM DICE, DARIN E. JONES, JOHN I. TRUJILLO, RICHARD LINDMARK
• Format: Patent
• Language: English
• Published: 29.09.2004
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to substituted polycyclic aryl and heteroaryl pyrazinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.