6-(((ARYLAND HETEROARYL)OXY)METHYL) NAPHTHALENE-2- CARBOXIMIDAMIDE DERIVATIVES, PREPARATION AND THERAPEUTIC APPLICATION THEREOF

• Main Authors: ALCOUFFE, CHANTAL, LASSALLE, GILBERT, DELLAC, GENEVIEVE, BELLEVERGUE, PATRICE, LATHAM, CHRISTOPHER, MALLART, SERGIO
• Format: Patent
• Language: English
• Published: 15.07.2004
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; APPARATUS THEREFOR; CHEMISTRY; GENERAL METHODS OF ORGANIC CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Pronalazak se odnosi na jedinjenja opšte formule (I) gde R1 predstavlja bilo atom vodonika, bilo amino grupu, bilo (C1-C4) alkil grupu, bilo (C1-C6) alkoksikarbonil grupu, bilo -OH grupu, R2 predstavlja bilo (C1-C6) alkil, bilo fenil ili benzil grupu bilo -CH2Q grupu, gde Q je heterociklična grupa; R3 i R5, na primer, predstavljaju nezavisno svaki od onog drugog bilo atom vodonika, bilo (C1-C4) alkil grupu, bilo -COOH grupu, bilo hidroksilnu grupu; R4 predstavlja bilo atom vodonika, bilo (C1-C4)alkil grupu, bilo -(CH2)p-COOR8 grupu; Z predstavlja bilo -CH- grupu, bilo atom azota. Pronalazak se takodje odnosi na postupke za dobijanje i terapeutsku primenu pomenutih jedinjenja. The invention concerns compounds of general formula (I) wherein: R1 represents either a hydrogen atom, or an amino group, or a C1-C4 alkyl group, or a C1-C6 alkoxycarbonyl group, or a -OH group; R2 represents either a C1-C6 alkyl group, or a phenyl or benzyl group, or a -CH2Q group, wherein Q is a heterocyclic group; R3 and R5 represent independently of each other for example either a hydrogen atom, or a C1-C4 alkyl group, or a -COOH group; R4 represents either a hydrogen atom, or a C1-C4 alkyl group, or a -(CH2)p-COOR8 group; Z represents either a -CH- group, or a nitrogen atom. The invention also concerns the methods of preparation and therapeutic use of said compounds.