ETHANOLATES OF SODIUM-HYDROGEN EXCHANGER TYPE-1 INHIBITOR

The invention relates to ethanolates of the NHE-1 inhibitor, N-(5-cyclopropyl-1-quinolin-5-yl-1H-pyrazole-4-carbonyl)-guanidine, crystalline forms of the ethanolates, methods of preparing the ethalolates, methods of treatment using the ethanolates and the mesylate salt of the NHE-1 inhibitor prepare...

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Bibliographic Details
Main Authors NORRIS, TIMOTHY, WEEKLY, RODNEY MATTHEW
Format Patent
LanguageEnglish
Published 25.05.2006
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to ethanolates of the NHE-1 inhibitor, N-(5-cyclopropyl-1-quinolin-5-yl-1H-pyrazole-4-carbonyl)-guanidine, crystalline forms of the ethanolates, methods of preparing the ethalolates, methods of treatment using the ethanolates and the mesylate salt of the NHE-1 inhibitor prepared using the ethanolates. Pronalazak se odnosi na enolate NHE-1 inhibitora, N-(5-ciklopropil-1-hinolin-5-il 1H-pirazol-4-karbonil)-gvanidina, kristalne oblike etanolata, postupke dobijanja etanolata, postupke lečenja polazeći od etanolata i metilsulfonatne soli NHE-1 inhibitora dobijenog od etanolata.[The invention relates to ethanolates of the NHE-1 inhibitor, N-(5-cyclopropyl-1-quinolin-5-yl-1H-pyrazole-4-carbonyl)-guanidine, crystalline forms of the ethanolates, methods of preparing the ethalolates, methods of treatment using the ethanolates and the mesylate salt of the NHE-1 inhibitor prepared using the ethanolates.
Bibliography:Application Number: YU2003P000005