PROCESS FOR OBTAINING OF ANHYDROUS TRANSDERMAL PREPARATION

• Main Authors: TOTH, ANTAL DR, MARMAROSI, KELLNER KATALIN, MAGYAR, KALMAN DR, SZEGO, ANDRAD DR, SZABO, Z. ANNA, SZUTS, TAMAS DR, LENGYEL, JOZSEF DR, SZABO, UJHELYI GABRIELLA, SZEKELY, ANNA, PINTER, JANOS DR
• Format: Patent
• Language: English
• Published: 05.11.1998
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMISTRY; COMPOSITIONS BASED THEREON; COMPOSITIONS OF MACROMOLECULAR COMPOUNDS; DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; ORGANIC MACROMOLECULAR COMPOUNDS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR CHEMICAL WORKING-UP

Postupak za dobijanje anhidrovanog transdermalnog preparata, naznačen time, što se 5-15% mas. optički aktivnog ili racemskog N-metil-N-(fenil-2-propil)-2-propinilamina ili N-metil-N-(1-(4-fluoro-fenil)-2-propil)-2-propinilamina ili njihove podesne soli inkorporira u smešu koja se sastoji od 40-70 mas. % tečnog polioksietilenglikola, 10-20 mas. % čvrstog polioksietilenglikola, 2-30 mas. % nejonskog površinski aktivnog sredstva, 2-20 mas. % propilenglikola i po potrebi mogu se dodati druga pomoćna sredstva. The invention concerns an anhydrous transdermal preparation comprising in a 20-100% lyotropic liquid crystalline arrangement: 5-15 w.% of optically active or racemic N-methyl-N-(phenyl-2-propyl)-2-propynylamine or N-methyl-N-(1-(4-fluoro-phenyl)-2-propyl)-2-propynylamine or their therapeutically acceptable salts, 40-70 w.% of liquid polyoxyethyleneglycol, 10-20 w.% of solid polyoxyethyleneglycol, 2-30 w.% of a nonionic surface active agent, 2-20 w.% of propyleneglycol, if desired 0.5-2 w.% of a polymer the a value of which is > 0.6, and if desired other auxiliary agents.