4-PYRIMIDINYL-N-ACYL-L-PHENYLALANINES

• Main Authors: TILLEY, JEFFERSON WRIGHT, SIDDURI, ACHYUTHARAO
• Format: Patent
• Language: English
• Published: 15.03.2005
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Coumpounds of Formula (I) are disclosed, wherein R1 to R6 are as defined in specification and which are inhibitors of binding between VCAM-1 and cells expressing VLA-4, and accordingly are useful for treating diseases whose symptoms and or damage are related to the binding of VCAM-1 to cells expressing VLA-4. Otkrivena su jedinjenja formule (I) u kojima su R1 do R6 definisani kao što je dato u specifikaciji i koja su inhibitori vezivanja izmedju VCAM-1 i ćelija koje istiskuju (ekspresuju) VLA-4 i koja su prema tome prikladna za lečenje bolesti čiji su simptomi i/ili povreda u vezi sa vezivanjem VCAM-1 za ćelije koje istiskuju (ekspresuju) VLA-4.[Coumpounds of Formula (I) are disclosed, wherein R1 to R6 are as defined in specification and which are inhibitors of binding between VCAM-1 and cells expressing VLA-4, and accordingly are useful for treating diseases whose symptoms and or damage are related to the binding of VCAM-1 to cells expressing VLA-4.