NOVEL URETHANES, THIO AND DITHIO ANALOGUES, THE SALTS THEREOF, MEDICAMENTS CONTAINING SAID COMPOUNDS, USE AND METHOD FOR THE PRODUCTION THEREOF

• Main Authors: MAIER, ROLAND, SCHILCHER, GEBHARD, EISELE, BERNHARD, ADELGOSS, GEBHARD, MULLER, PETER
• Format: Patent
• Language: English
• Published: 19.09.2002
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; FODDER; FOODS OR FOODSTUFFS; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

The present invention relates to urethanes and thio and dithio analogues of general formula (I), wherein m, n, A, X, Y and R1-R8 are as defined in claim 1. The invention also relates to enantiomers, diastereomers and salts thereof, especially physiologically acceptable acid additive salts with valuable properties exhibiting an inhibiting effect on cholesterol biosynthesis, in addition to medicaments containing said compounds, the use thereof and a method for the production thereof. Ovaj pronalazak se odnosi na uretane, kao i na njihove tio- i ditio-analoge, opšte formule (I), u kojoj su m, n, A, X, Y i R1 do R8 definisani kao u zahtevu 1, na njihove enantiomere, dijastereomere i njihove soli, naročito njihove fiziološki podnošljive adicione soli sa kiselinom, koji imaju dragocena svojstva, naročito inhibiciono dejstvo na biosintezu holesterola, na lekove koji sadrže ova jedinjenja, na njihovu primenu i na postupke za njihovo pripremanje.[The present invention relates to urethanes and thio and dithio analogues of general formula (I), wherein m, n, A, X, Y and R1-R8 are as defined in claim 1. The invention also relates to enantiomers, diastereomers and salts thereof, especially physiologically acceptable acid additive salts with valuable properties exhibiting an inhibiting effect on cholesterol biosynthesis, in addition to medicaments containing said compounds, the use thereof and a method for the production thereof.