CONTROLLED RELEASE POLYMERIC COMPOSITIONS OF BONE GROWTH PROMOTING COMPOUNDS

• Main Authors: ZHOU, MINGXING, KORSMEYER, RICHARD WILKE, PARALKAR, VISHWAS MADHAV, DUNN, RICHARD LEE, JEFFERS, SCOTT ALEXANDER, DUMONT, FRANCIS, LI, MEI
• Format: Patent
• Language: English
• Published: 17.08.2006
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention is directed to an improved system for controlled release of a bone growth promoting compound and to a flowable composition for its formation. The flowable composition is composed of a bone growth promoting compound, a thermoplastic polymer and an organic solvent. The flowable composition is capable of forming a biodegradable and/or bioerodible microporous, solid polymer matrix. The matrix is useful as an implant in patients (humans and animals) for delivery of a bone growth promoting compound to certain tissues. Ovaj pronalazak je usmeren na poboljšani sistem za kontrolisano oslobađanje jedinjenja koja pomažu rast kosti i na tečljivi preparat za njegovo formiranje. Ovaj tečljivi preparat je sačinjen od jedinjenja koje pomaže rast kosti, termoplastičnog polimera i organskog rastvarača. Ovaj tečljivi preparat je u stanju da formira biodegradabilnu i/ili bioerozivnu mikroporoznu čvrstu polimernu matricu. Ova matrica je korisna kao implantat u pacijentima (humanim i animalnim) za oslobađanje jedinjenja koje pomaže rast kosti u nekim tkivima.[The present invention is directed to an improved system for controlled release of a bone growth promoting compound and to a flowable composition for its formation. The flowable composition is composed of a bone growth promoting compound, a thermoplastic polymer and an organic solvent. The flowable composition is capable of forming a biodegradable and/or bioerodible microporous, solid polymer matrix. The matrix is useful as an implant in patients (humans and animals) for delivery of a bone growth promoting compound to certain tissues.