PROCESS FOR OBTAINING THIENO-PYRIDINE DERIVATIVES

A method of preparing thienopyridine derivatives of the formula: **(See formula)** in which R1 represents an optionally substituted alcoholic, aryl or aralcohyl radical, and R2 and R3 represent hydrogen or a lower alcoholic, aryl or heterocyclic radical, characterized in that (a) a derivative of for...

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Bibliographic Details
Main Author BRAYE E
Format Patent
LanguageEnglish
Published 31.05.1982
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:A method of preparing thienopyridine derivatives of the formula: **(See formula)** in which R1 represents an optionally substituted alcoholic, aryl or aralcohyl radical, and R2 and R3 represent hydrogen or a lower alcoholic, aryl or heterocyclic radical, characterized in that (a) a derivative of formula is reacted: **(See formula)** in which R2 and R3 are as defined for formula (I) and X represents hydrogen, or an alkali metal, or a MgY radical in which Y represents a halogen, with a halogen-sulfonated derivative of formula Hal- SO2-R4 (III) in which Hal represents a halogen and represents an optionally substituted alcoholic, aryl or aralcohyl group, thus obtaining a compound of formula: **(See formula)** that (b) is then reacted with an amine of formula R1-NH2 (V), wherein R1 is as defined for formula (I), to obtain a compound of formula: **(See formula)** which (c) is then cyclized by means of formaldehyde to give the derivative of formula (I). (Machine-translation by Google Translate, not legally binding)
Bibliography:Application Number: YU19760000267