ISOQUINOLINES AS UROKINASE INHIBITORS

Compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein one of R1 and R2 is H and the other is N=C(NH2)2 or NHC(=NH)NH2, and the other substituents are as defined herein, are urokinase (uPA) inhibitors. Jedinjenja formule (I) i njihove farmaceutski prihvatljive soli, gde jeda...

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Bibliographic Details
Main Authors BARBER, CHRISTOPHER GORDON, ROGER, PETER DICKINSON, PAUL, VINCENT FISH
Format Patent
LanguageEnglish
Published 15.11.2002
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein one of R1 and R2 is H and the other is N=C(NH2)2 or NHC(=NH)NH2, and the other substituents are as defined herein, are urokinase (uPA) inhibitors. Jedinjenja formule (I) i njihove farmaceutski prihvatljive soli, gde jedan od R1 i R2 je H a drugi je N=C(NH2)2 a drugi supstituenti se kao što je definisano u opisu su urokinazni (uPA) inhibitori.[Compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein one of R1 and R2 is H and the other is N=C(NH2)2 or NHC(=NH)NH2, and the other substituents are as defined herein, are urokinase (uPA) inhibitors.
Bibliography:Application Number: YU20000000211