INCLUSION COMPLEXES OF ARYL-HETEROCYCLIC SALTS

• Main Authors: KIM, YESOOK, JOHNSON, KEVIN CHARLES, SHANKER, RAVI MYSORE
• Format: Patent
• Language: English
• Published: 27.12.1999
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Opisane su kompozicije supstanci koje obuhvataju farmaceutski prihvatljivu so aril-heterocikličnog jedinjenja, kao što je ziprasidon u ciklodekstrinu. Poželjni ciklodekstrini su SBECD i HPBCD. Kompozicija može obuhvatiti suvu smešu, suvi inkluzioni kompleks ili vodeni rastvor. Poželjno je da so/ciklodekstrin inkluzioni kompleks obezbedi količinu ziprasidona od najmanje 2,5 mgA/ml kada je kompleks rastvoren u vodi kao 40 % t/z. Poželjne su različite ziprasidonove soli uključujući mezilate, ezilate, bezilate, tartarate, napsilate i tozilate. Compositions of matter comprising a phamaceutically acceptable salt of an arylheterocyclic compound, such as ziprasidone, in a cyclodextrin. Preferred cyclodextrins are SBECD and HPBCD. The composition can comprise a dry mixture, a dry inclusion complex or an aqueous solution. The salt/cyclodextrin inclusion complex preferably provides an amount of ziprasidone of at least 2.5 mgA/ml when the complex is dissolved in water at 40% w/v. A variety of ziprasidone salts are preferred, including the mesylate, esylate, besylate, tartrate, napsylate, and tosylate.