PROCESS FOR MAKING PHARMACEUTICALLY USABLE 2-METHYL-4-HYDROXY-2H-1,2-BENZOTHIAZINE-1,1-DIOXIDE-3(N-2-PYRIDILE)-CARBOXAMIDE

Method for the preparation of a 2-methyl-4-hydroxy-2H-1,2-benzotiacin-1,1-dioxide-3- (N-2-piridyl) -carboxamide. You considered to reaction 2-methyl-2 acid -mesiloxy-2H-1,2-benzotiacin-1,1-dioxido-3-carboxylic of formula (II) with 2-aminopyridine in the presence of tionillo chloride in an inert solv...

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Bibliographic Details
Main Authors PIPPURI A.K, KURIMO I.R.H, NORE P.T, KAIRISALO P.J, HONKANEN E.J, JOHANSSON M.E.V, KARHU M
Format Patent
LanguageEnglish
Published 31.12.1986
Edition2
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Method for the preparation of a 2-methyl-4-hydroxy-2H-1,2-benzotiacin-1,1-dioxide-3- (N-2-piridyl) -carboxamide. You considered to reaction 2-methyl-2 acid -mesiloxy-2H-1,2-benzotiacin-1,1-dioxido-3-carboxylic of formula (II) with 2-aminopyridine in the presence of tionillo chloride in an inert solvent to prepare the desired compound of formula (I). The reaction temperature is included between 40 and 80 jc and as solitary inert, chloride hydrocarbons are used, using a time of 2 to 3 hours. (Machine-translation by Google Translate, not legally binding)
Bibliography:Application Number: YU19860001496