POSTUPAK ZA DOBIJANJE NOVIH PREPARATA

• Main Author: MARKHAM, R.G
• Format: Patent
• Language: English
• Published: 20.10.1993
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

POSTUPAK ZA DOBIJANJE NOVIH PREPARATA, pronalaskom je opisan postupak za dobijanje preparata koji sadrži terapeutski aktivno jedinjenje koje ima molekulsku masu ispod oko 5 000, koje ima kiselinsku funkcionalnu grupu i pKa 6 na pH=7,4 koje se normalno eliminiše iz tela putem izlučivanja bubrežnim kanalom za organske anjone, na primer, Vitamin C i bar jedno jedinjenje odabrano iz klase koju čine L-treonska, L-ksilonska i L-liksonska kiselina i njihove jestive soli aldono-laktona i aldono-laktida. A therapeutic compsn. comprises: (a) a therapeutically active cpd. having (i) a mol.wt. below 5000, (ii) an acidic-functional gp. and a pKa of equal to or less than 6 at the physiological pH of 7.4, and (iii) which is normally eliminated unmetablised via the renal tubular secretion pathway for organic anions; and (b) at least one cpd. selected from the gp. consisting of L-threonic, L-xylonic and L-lyxonic acids and their edible non-toxic salts, aldonolactones and aldono lactides. Also claimed is a Vitamin C compsn., a method of establishing high vitamin C levels, a method of suppressing the excretion of organic anions, and a method of improving the absorption of organic anions in body tissue.