INHIBITORS OF SEROTONIN REUPTAKE

A compound of Formula (I) where A-B is -C=CH- or -CHCH2-; n is 0 or 1; R is H or C1-C4 alkyl; R is H, methyl, or ethyl and Aryl is naphthyl or heteroaryl, each optionally monosubstituted with a substituent selected from the group consisting of H, halo, hydroxy, C1-C4 alkyl, C1-C4 alkoxy, cyano, nitr...

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Bibliographic Details
Main Authors ROCCO, VINCENT, PATRICK, KOCH, DANIEL, JAMES
Format Patent
LanguageEnglish
French
Published 23.12.1999
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A compound of Formula (I) where A-B is -C=CH- or -CHCH2-; n is 0 or 1; R is H or C1-C4 alkyl; R is H, methyl, or ethyl and Aryl is naphthyl or heteroaryl, each optionally monosubstituted with a substituent selected from the group consisting of H, halo, hydroxy, C1-C4 alkyl, C1-C4 alkoxy, cyano, nitro, carboaxamido, and trifluoromethyl; or pharmaceutically acceptable salts or hydrates thereof, provided that when n is 1, A-B is -CHCH2-, and a method for the inhibition of serotonin reuptake in mammals. L'invention concerne un composé représenté par la formule (I), ou bien des sels ou des hydrates pharmaceutiquement acceptables dudit composé. Dans ladite formule, A-B est -C=CH- ou CHCH2-; n vaut 0 ou 1 ; R est H ou alkyle C1-4; R est H, méthyle ou éthyle ; et Aryle est naphtyle ou hétéroaryle, chacun éventuellement monosubstitué via un substituant qui fait partie de la liste suivante : H, halo, hydroxy, alkyle C1-4, alcoxy C1-4, cyano, nitro, carboxamido et trifluorométhyle, à condition que, lorsque n vaut 1, A-B est -CHCH2-. L'invention concerne également un procédé relatif à l'inhibition de la réabsorption de la sérotonine chez les mammifères.
Bibliography:Application Number: WO1999US12473