PROCESSES TO GENERATE SUBMICRON PARTICLES OF WATER-INSOLUBLE COMPOUNDS
Submicron particles of water-insoluble compounds, particularly drugs, are prepared by simultaneously stabilizing microparticulate suspensions of same with surface modifier molecules by rapid expansion into an aqueous medium from a compressed solution of the compound and surface modifiers in a liquef...
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Main Authors | , , , , , |
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Format | Patent |
Language | English French |
Published |
23.12.1999
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Edition | 6 |
Subjects | |
Online Access | Get full text |
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Summary: | Submicron particles of water-insoluble compounds, particularly drugs, are prepared by simultaneously stabilizing microparticulate suspensions of same with surface modifier molecules by rapid expansion into an aqueous medium from a compressed solution of the compound and surface modifiers in a liquefied gas and optionally homogenizing the aqueous suspension thus formed with a high pressure homogenizer.
L'invention concerne la préparation de particules submicroniques de composés insolubles dans l'eau, notamment de médicaments, qui comporte les étapes consistant à stabiliser simultanément des suspensions de microparticules de ceux-ci avec des molécules de modificateur de surface par expansion rapide dans un milieu aqueux, à partir d'une solution comprimée du composé et de modificateurs de surface dans un gaz liquéfié; et éventuellement homogénéiser la suspension aqueuse ainsi formée à l'aide d'un homogénéisateur haute pression. |
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Bibliography: | Application Number: WO1999US13755 |