MODULATORS OF PROTEIN TYROSINE PHOSPHATASES

• Main Authors: ANDERSEN, HENRIK, SUNE, RIPKA, WILIAM, CHARLES, AXE, FRANK, URBAN, SU, JING, UYEDA, ROY, TERUYUKI, JUDGE, LUKE, MILBURN, IVERSEN, LARS, FOGH, JEPPESEN, CLAUS, BEKKER, OLSEN, OLE, HVILSTED, JEPPESEN, LONE, HOLSWORTH, DANIEL, DALE, RICHTER, LUTZ, STEFAN DI, MOELLER, NIELS, PETER, HUNDAHL, GE, YU, JONES, TODD, KEVIN, BAKIR, FARID, VAGNER, JOSEF, BRANNER, SVEN
• Format: Patent
• Language: English; French
• Published: 16.09.1999
• Edition: 6
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPases, PTPs) such as PTP1B, TC-PTP, CD45, SHP-1, SHP-2, PTP alpha , PTP epsilon , PTP mu , PTP delta , PTP sigma , PTP zeta , PTP beta , PTPD1, PTPD2, PTPH1, PTP-MEG1, PTP-LAR, and HePTP. These compounds are indicated in the management or treatment of a broad range of diseases such as autoimmune diseases, acute and chronic inflammation, osteoporosis, various forms of cancer and malignant diseases, and type I diabetes and type II diabetes. Cette invention se rapporte à de nouveaux composés, à de nouvelles compositions, à des procédés pour leur utilisation et à des procédés pour leur fabrication, ces composés constituant des inhibiteurs pharmacologiquement utiles des protéine-tyrosine-phosphatases (PTPases, PTP) telles que PTP1B, TC-PTP, CD45, SHP-1, SHP-2, PTP alpha , PTP epsilon , PTP mu , PTP delta , PTP sigma , PTP zeta , PTP beta , PTPD1, PTPD2, PTPH1, PTP-MEG1, PTP-LAR ET HePTP. Ces composés sont indiqués dans la prise en charge ou le traitement d'une large gamme de maladies, telles que les maladies auto-immunes, les inflammations aiguës et chroniques, l'ostéoporose, diverses formes de cancer et d'affections malignes, ainsi que le diabète de type I et le diabète de type II.