OPTICAL BIOPSY SYSTEM AND METHODS FOR TISSUE DIAGNOSIS

A system characterized tissue using fluorescence spectroscopy, such as light-induced fluorescence. Native fluorescence ("autofluorescence") from endogenous tissue without requiring fluorescence-enhancing agents is used to distinguish between normal tissue, hyperplastic tissue, adenomatous...

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Main Authors YAGER, JOHN, G, SIEVERT, CHESTER, E., JR, WILSON, SCOTT, R, ZIMMERMANN, RONALD, R, WALSH, DAVID, R, MCMAHON, BRIAN, T, PALME, ROBERT, A
Format Patent
LanguageEnglish
French
Published 16.09.1999
Edition6
Subjects
DIAGNOSIS
HUMAN NECESSITIES
HYGIENE
IDENTIFICATION
MEDICAL OR VETERINARY SCIENCE
SURGERY
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Summary:A system characterized tissue using fluorescence spectroscopy, such as light-induced fluorescence. Native fluorescence ("autofluorescence") from endogenous tissue without requiring fluorescence-enhancing agents is used to distinguish between normal tissue, hyperplastic tissue, adenomatous tissue, and adenocarcinomas. The system provides endoscopic image enhancement for easy location of a tissue site for optical biopsy tissue characterization. The system allows the use of an integrated endoscopic diagnosis and treatment device for immediate diagnosis and treatment without interchanging equipment and relocating the tissue site. The system is also integrated with existing endoscopy equipment for initiating and displaying the diagnosis. The system provides an adjunctive tool to histopathological tissue classification or, alternatively, further treatment is based on the optical biopsy system diagnosis itself. L'invention porte sur un système de spectroscopie de fluorescence permettant de déterminer la nature de tissus. On utilise à cet effet la fluorescence naturelle de tissus endogènes sans recourir à des agents renforçateurs de fluorescence pour distinguer les tissus normaux, hyperplastiques, adénomateux ou d'adénocarcinomes. Ledit système: fournit une image endoscopique agrandie permettant de localiser aisément l'emplacement d'un tissu pour le caractériser par biopsie optique; permet l'utilisation d'un dispositif intégré de diagnostic et de traitement immédiats sans avoir à changer d'instrument ou à relocaliser à l'emplacement du tissu; peut s'intégrer à des équipements d'endoscopie existants pour lancer ou afficher un diagnostic; constitue un outil additionnel de classification histopathologique des tissus; ou permet des traitements ultérieurs se basant sur son diagnostic de biopsie optique.
Bibliography:Application Number: WO1999US05134