DESERT HEDGEHOG RELATED NUCLEIC ACIDS AND PROTEINS

The invention provides isolated nucleic acid, proteins and peptides, wherein said proteins and peptides are related to the Hedgehog family of proteins. Also provided are vectors and transformed host cells for expressing said proteins, and a method for identifying compounds that bind and/or modulate...

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Bibliographic Details
Main Authors KING, MICHAEL, WILLIAM, EDMONDS, BRIAN, TAYLOR, SMITH, ROSAMUND, CAROL
Format Patent
LanguageEnglish
French
Published 12.08.1999
Edition6
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:The invention provides isolated nucleic acid, proteins and peptides, wherein said proteins and peptides are related to the Hedgehog family of proteins. Also provided are vectors and transformed host cells for expressing said proteins, and a method for identifying compounds that bind and/or modulate the activity of said proteins, and pharmaceutical compositions and methods for treating spinal cord injury, male infertility, male menopause, tumor growth, and central nervous system disorders. L'invention concerne des acides nucléiques, des protéines et des peptides isolés, lesdites protéines et lesdits peptides appartenant à la famille des protéines du hérisson. Elle concerne également des vecteurs et des cellules hôtes transformées servant à exprimer lesdites protéines, ainsi qu'un procédé servant à identifier des composés se fixant audites protéines et/ou en modulant l'activité, des compositions pharmaceutiques et des procédés servant à traiter des lésions de la moelle épinière, la stérilité masculine, l'andropause, la croissance tumorale et des maladies du système nerveux central.
Bibliography:Application Number: WO1999US02440