BIS-PHOSPHONATE CONFUGATES WITH ALKYLATING MOIETIES HAVING ANTITUMOR ACTIVITY

• Main Authors: CONTI, MARCO, D'ALO', SIMONETTA, LIVI, VALERIA, SPINELLI, SILVANO, MENTA, ERNESTO
• Format: Patent
• Language: English; French
• Published: 08.10.1998
• Edition: 6
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

The present invention relates to conjugates of 3-carboxy-4,4'-dihydroxyphosphorylbutenoic acids with alkylating agents. Such derivatives are endowed with marked antitumor activity, especially against multiple myeloma. The present invention relates as well to a process for the preparation thereo...