UNSATURED FATTY ACID ANHYDRIDES FOR USE IN THE THERAPY

• Main Authors: BRADLEY, PAUL, PITT, ANDREA, MANKU, MEHAR, SINGH, MCMORDIE, AUSTIN, HORROBIN, DAVID, FREDERICK, KNOWLES, PHILIP
• Format: Patent
• Language: English; French
• Published: 17.09.1998
• Edition: 6
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

Compounds of the following acid anhydride structure, when for use in therapy in non-aqueous formulations, particularly for securing rapid uptake in the constituent fatty acids of the blood plasma and red cell lipids: R - O - R where R is an acyl group derived from a bioactive unsaturated fatty acid particularly a C16-26 preferably C18-22 fatty acid with two to six cis or trans double bonds, and R is an acyl group as R , the same or different. L'invention concerne des composés présentant la structure d'anhydride d'acide R - O - R , utilisés dans le cadre d'une thérapie en formulations non aqueuses, notamment pour assurer une absorption rapide dans les acides gras constitutifs du plasma sanguin et des lipides de globules rouges. Dans cette structure, R représente un groupe acyle dérivé d'un acide gras bioactif insaturé, notamment un acide gras C16-26, de préférence C18-22, avec deux à six double liaisons cis ou trans, R représentant un groupe acyle comme R , identique ou différent.