SYNTHESIS OF ACYCLIC NUCLEOSIDE DERIVATIVES

• Main Authors: TIAN, ZHENPING, WAYNE, GREG, ZHANG, WEIJIANG, SINGAM, PULLA, REDDY, GATES, BRADLEY, D, LANNOYE, GREG, CHANG, SOU-JEN, RILEY, DAVID, A, RASMUSSEN, MICHAEL, LEANNA, M., ROBERT, KOLACZKOWSKI, LAWRENCE, LUKIN, KIRILL, L, PATEL, RAMESH, R, BHAGAVATULA, LAKSHMI, MORTON, HOWARD, HANNICK, STEVEN, M, TIEN, JIEN-HEH, J, NARAYANAN, BIKSHANDARKOR, A
• Format: Patent
• Language: English; French
• Published: 13.08.1998
• Edition: 6
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; BEER; BIOCHEMISTRY; CHEMISTRY; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

Methods and novel intermediates for the preparation of acyclic nucleoside derivatives of formula (I) where one of R1 and R2 is an amino acid acyl group and the other of R1 and R2 is a -C(O)C3-C21 saturated or monounsaturated, optionally substituted alkyl and R3 is OH or H; or a pharmaceutically acceptable salt thereof. La présente invention concerne des procédés et de nouveaux intermédiaires permettant de préparer des dérivés de nucléoside acyclique répondant à la formule (I), dans laquelle R1 et R2 sont l'un, un groupe acide aminé acyle et l'autre, un -C(O)C3-C21 saturé ou monoinsaturé, facultativement alkyle substitué, et R3 est OH ou H; ou un sel pharmaceutiquement acceptable de ces derniers.