Gene therapy delivery system for targeting to endothelia
A composition comprising biodegradable microspheres that act as carriers for the delivery of DNA to the endothelial cells of a vascular bed, wherein the microspheres carry a net negative charge and to which is adsorbed positively charged particles of a smaller size, wherein such positively charged p...
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Main Author | |
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Format | Patent |
Language | English |
Published |
12.03.1998
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Edition | 6 |
Subjects | |
Online Access | Get full text |
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Summary: | A composition comprising biodegradable microspheres that act as carriers for the delivery of DNA to the endothelial cells of a vascular bed, wherein the microspheres carry a net negative charge and to which is adsorbed positively charged particles of a smaller size, wherein such positively charged particles comprise a conjugate of DNA and a cationic compacting agent. |
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Bibliography: | Application Number: WO1997GB01860 |