INHIBITORS OF PROTEIN FARNESYL TRANSFERASE

Novel inhibitors of protein farnesyl transferase enzymes are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating cancer, restenosis, psoriasis, endometriosis, atherosclerosis, or viral infections. Cette invention concerne de nou...

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Main Authors DOBRUSIN, ELLEN, M, LEONARD, DANIELE, M, KALTENBRONN, JAMES, STANLEY, SHULER, KEVON, R, DOHERTY, ANNETTE, MARIAN, MCNAMARA, DENNIS, JOSEPH, SEBOLT-LEOPOLD, JUDITH
Format Patent
LanguageEnglish
French
Published 27.11.1997
Edition6
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Novel inhibitors of protein farnesyl transferase enzymes are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating cancer, restenosis, psoriasis, endometriosis, atherosclerosis, or viral infections. Cette invention concerne de nouveaux inhibiteurs d'enzymes du type farnésyltransférase de protéines, ainsi que des procédés de préparations de ces inhibiteurs et des compositions les contenant. Ces inhibiteurs sont utiles dans le traitement du cancer, de la resténose, du psoriasis, de l'endométriose, de l'athérosclérose ou, encore, d'infections virales.
Bibliography:Application Number: WO1997US06591