TRICYCLIC FUSED COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Substituted heteroaromatic compounds, in particular substituted tricyclic fused compounds in which one terminal ring is pyridine or pyrimidine, are protein tyrosine kinase inhibitors. The compounds are described as are methods for their preparation, pharmaceutical compositions including such compoun...

Full description

Saved in:
Bibliographic Details
Main Authors VILE, SADIE, BARRACLOUGH, PAUL, WALKER, ANN, LOUISE, HUDSON, ALAN, THOMAS, FRANZMANN, KARL, WITOLD, PAGE, MARTIN, JOHN, MCKEOWN, STEPHEN, CARL
Format Patent
LanguageEnglish
French
Published 17.04.1997
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online AccessGet full text

Cover

More Information
Summary:Substituted heteroaromatic compounds, in particular substituted tricyclic fused compounds in which one terminal ring is pyridine or pyrimidine, are protein tyrosine kinase inhibitors. The compounds are described as are methods for their preparation, pharmaceutical compositions including such compounds and their use in medicine, for example in the treatment of psoriasis, fibrosis, atherosclerosis, restenosis, auto-immune disease, allergy, asthma, transplantation rejection, inflammation, thrombosis, nervous system diseases, and cancer. Les composés hétéroaromatiques substitués, en particulier les composés condensés tricycliques substitués dans lequel un noyau terminal est une pyridine ou une pyrimidine, constituent des inhibiteurs de la tyrosine kinase. On décrit de tels composés ainsi des procédés permettant de les préparer, des compositions pharmaceutiques contenant ces composés et leur utilisation en médecine, par exemple pour traiter: psoriasis, fibrose, athérosclérose, resténose, maladies auto-immunes, allergies, asthme, rejet de greffon, inflammations, thrombose, maladies du système nerveux et cancer.
Bibliography:Application Number: WO1996EP04396