STEROID RECEPTOR COACTIVATOR COMPOSITIONS AND METHODS OF USE

• Main Authors: TSAI, MING-JER, O'MALLEY, BERT, O, TSAI, SOPHIA, Y, ONATE, SERGIO
• Format: Patent
• Language: English; French
• Published: 20.03.1997
• Edition: 6
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BEER; BIOCHEMISTRY; CARE OF BIRDS, FISHES, INSECTS; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NEW BREEDS OF ANIMALS; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; SPIRITS; TRAPPING; VINEGAR; WINE

The present invention relates to SRC-1 polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of the foregoing. Methods for enhancing and inhibiting transcription by providing SRC-1 polypeptides or fragments thereof to a cell. Polypeptides coactivateurs 1 de récepteurs de stéroïdes (SRC-1), acides nucléiques codant lesdits polypeptides, cellules, tissus et animaux contenant lesdits acides nucléiques, anticorps contre lesdits polypeptides, dosages utilisant lesdits polypeptides et procédés concernant tous les éléments susmentionnés. Des procédés permettant de favoriser et d'inhiber la transcription en fournissant à une cellule des polypeptides SRC-1 ou des fragments desdits polypeptides sont également décrits.