RECOMBINANT POXVIRUS - CYTOMEGALOVIRUS COMPOSITIONS AND USES

Attenuated recombinant viruses containing DNA encoding an HCMV antigen, as well as methods and compositions employing the viruses, expression products therefrom, and antibodies generated from the viruses or expression products, are disclosed and claimed. The recombinant viruses can be NYVAC or ALVAC...

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Bibliographic Details
Main Authors PINCUS, STEVEN, E, PAOLETTI, ENZO, KAUFFMAN, ELIZABETH, K, COX, WILLIAM, I
Format Patent
LanguageEnglish
French
Published 12.12.1996
Edition6
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Summary:Attenuated recombinant viruses containing DNA encoding an HCMV antigen, as well as methods and compositions employing the viruses, expression products therefrom, and antibodies generated from the viruses or expression products, are disclosed and claimed. The recombinant viruses can be NYVAC or ALVAC recombinant viruses. The recombinant viruses and gene products therefrom and antibodies generated by the viruses and gene products have several preventive, therapeutic and diagnostic uses. The DNA of the recombinant viruses can be used as probes or for generating PCR primers. L'invention concerne des virus de recombinaison atténués contenant de l'ADN codant un antigène de CMV humain, ainsi que des méthodes et des compositions dans lesquelles lesdits virus sont utilisés, des produits d'expression de ces derniers et des anticorps générés à partir desdits virus ou desdits produits d'expression. Les virus de recombinaison peuvent être des virus de recombinaison NYVAC ou ALVAC. Les virus de recombinaison et leurs produits géniques ainsi que les anticorps générés par ceux-ci ont plusieurs applications préventives, thérapeutiques et diagnostiques. L'ADN des virus de recombinaison selon l'invention peut être utilisé comme sonde ou pour générer des amorces à PCR.
Bibliography:Application Number: WO1996US09454