1-PHENOXY-3-N-ALKYLAMINOPROPAN-2-OL HALOGEN DERIVATIVES USEFUL AS MYOCARDIAL beta ADRENERGIC RECEPTOR MARKERS AND AS beta -BLOCKING AGENTS

Practolol halogenated derivatives, useful as myocardial beta adrenergic receptor markers, are of formula (I): in which R can be various groups, for example, an isopropyl group, R is a group of formula CH=CHX, CCX, O-(CH2)pX or OCH2CH=CHX, with X being an optionally radioactive halogen atom, R is O o...

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Main Authors MATHIEU, JEAN-PAUL, VIDAL, MICHEL, MAJID, SAMIA, DEMENGE, PIERRE, APPARU, MARCEL, GHEZZI, CATHERINE, PASQUALINI, ROBERTO, MANUCLAIRE, LAURENT, FAGRET, DANIEL
Format Patent
LanguageEnglish
French
Published 11.01.1996
Edition6
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Practolol halogenated derivatives, useful as myocardial beta adrenergic receptor markers, are of formula (I): in which R can be various groups, for example, an isopropyl group, R is a group of formula CH=CHX, CCX, O-(CH2)pX or OCH2CH=CHX, with X being an optionally radioactive halogen atom, R is O or NHCO and n is equal to 0, 1 or 2. When X is 123I, the derivatives of the invention can be used as markers for assaying myocardial beta adrenergic receptors. Practolol halogenated derivatives, useful as myocardial beta adrenergic receptor markers, are of formula (I): in which R can be various groups, for example, an isopropyl group, R is a group of formula CH=CHX, CCX, O-(CH2)pX or OCH2CH=CHX, with X being an optionally radioactive halogen atom, R is O or NHCO and n is equal to 0, 1 or 2. When X is 123I, the derivatives of the invention can be used as markers for assaying myocardial beta adrenergic receptors. L'invention concerne des dérivés halogénés du practolol utilisables comme marqueurs des récepteurs beta adrénergiques myocardiques. Ces dérivés halogénés répondent à la formule (I) dans laquelle R peut être divers groupes, par exemple le groupe isopropyle, R représente un groupe de formule CH=CHX, CCX, O-(CH2)pX ou OCH2CH=CHX avec X représentant un atome d'halogène éventuellement radioactif, R est O ou NHCO et n est égal à 0, 1 ou 2. Lorsque X représente 123I, on peut les utiliser comme marqueurs pour l'examen des récepteurs beta -adrénergiques myocardiques.
Bibliography:Application Number: WO1995FR00870