AMINOLINE-N-OXIDE ANTIMICROBIALS FOR USE AGAINST H. PYLORI INFECTIONS

The use of a compound with structural formula (I) or the N-oxide thereof, wherein R1 is H or lower alkyl and R2 is C1-20 alkyl or C2-20 alkenyl with one or two unsaturated bonds, or a pharmaceutically acceptable salt, ester or salt of such ester or amide of such compounds, in the manufacture of a me...

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Bibliographic Details
Main Authors TAYLOR, GRAHAM, WALTER, LACEY, SANDRA, LYNN
Format Patent
LanguageEnglish
French
Published 02.11.1995
Edition6
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The use of a compound with structural formula (I) or the N-oxide thereof, wherein R1 is H or lower alkyl and R2 is C1-20 alkyl or C2-20 alkenyl with one or two unsaturated bonds, or a pharmaceutically acceptable salt, ester or salt of such ester or amide of such compounds, in the manufacture of a medicament for treating infection by microaerophilic bacteria, especially Helicobacter pylori. 2-heptyl-4-hydroxyquinoline, 2-nonyl-4-hydroxyquinoline, 2-nonenyl-4-hydroxyquinoline and their N-oxides are preferred. On décrit un composé de formule structurelle (I) ou son N-oxyde, où R1 représente alkyle C1-20 ou alcényle C2-20 dotés d'une ou deux liaisons insaturées, ou bien un de ses sels, esters, ou sels d'un tel ester ou un amide de ce composé tous devant être acceptables sur le plan pharmacologique. Ils entrent dans la composition d'un médicament permettant de traiter une infection due à des bactéries micro-aérophiliques et notamment à Hélicobacter pylori. On préfère l'utilisation de 2-heptyl-4-hydroxyquinoline, 2-nonyl-4-hydroxyquinoline, 2-nonenyl-4-hydroxyquinoline et de leurs N-oxydes.
Bibliography:Application Number: WO1995GB00886