ASSAYS FOR IMMUNOSUPPRESSANTS

• Main Authors: WENNER, PETER, BAUMANN, GOETZ, DI PADOVA, FRANCO, E
• Format: Patent
• Language: English; French
• Published: 28.09.1995
• Edition: 6
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; TESTING; VINEGAR; WINE

Quantitative reporter gene assays allowing for highly precise measurements of immunosuppressants in bodily fluids are provided, e.g., an IL-2 reporter gene assay for measuring blood levels of immunosuppressive cyclosporins and ascomycins (e.g., cyclosporin A and FK-506), and a c-jun reporter gene assay for measuring blood levels of immunosuppressive rapamycins. Analyses quantitatives de gènes reporteurs permettant des mesures extrêmement précises des immunosuppresseurs dans des fluides organiques, par exemple une analyse du gène reporteur IL-2 destinée à mesurer la concentration sanguine en cyclosporines et ascomycines à effet immunosuppresseur (par exemple la cyclosporine A et FK-506), et une analyse du gène reporteur c-jun destinée à mesurer la concentration sanguine en rapamycines à effet immunosuppresseur.