HETEROCYCLIC COMPOUNDS AS PLATELET AGGREGATION INHIBITORS

A compound of the general formula(M1)n-Q-(M2)1-n-L-AIwherein: n is 0 or 1; M1 is an amino group; Q is an aromatic heterocyclic group containing a basic nitrogen atom; M2 is an imino group; L is a template group; and A is an acidic group, or an ester or amide derivative thereof, or a sulphonamide gro...

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Main Authors RAYNER, JOHN, WALL, CAULKETT, PETER, WILLIAM, RODNEY, BREWSTER, ANDREW, GEORGE, SHUTE, RICHARD, EDEN, PEARCE, ROBERT, JAMES, SMITHERS, MICHAEL, JAMES, FAULL, ALAN, WELLINGTON, MILLS, STUART, DENNETT, WAYNE, MICHAEL, GARTH
Format Patent
LanguageEnglish
Published 22.12.1994
Edition5
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A compound of the general formula(M1)n-Q-(M2)1-n-L-AIwherein: n is 0 or 1; M1 is an amino group; Q is an aromatic heterocyclic group containing a basic nitrogen atom; M2 is an imino group; L is a template group; and A is an acidic group, or an ester or amide derivative thereof, or a sulphonamide group; and pharmaceutically acceptable salts and pro-drugs thereof, for use in the treatment of a disease in which platelet aggregation mediated by the binding of adhesion molecules to GPIIb-IIIa is involved. Novel compounds are also disclosed.
Bibliography:Application Number: WO1994GB00648