ANTIHYPERTENSIVE 5-[(IMIDAZO[4,5-b]PYRIDIN-3-YL)METHYL]BENZOFURAN DERIVATIVES

• Main Author: JUDD, DUNCAN, BRUCE
• Format: Patent
• Language: English; French
• Published: 26.05.1994
• Edition: 5
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The invention relates to the compounds: N-[2-[3-chloro-5-[(5,7-dimethyl-2-ethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl]-2-benzofuranyl]phenyl]trifluoromethanesulphonamide; 3-[[3-chloro-2-[2-[[(trifluoromethyl)sulphonyl]amino]phenyl]-5-benzofuranyl]methyl]-2-ethyl-7-methyl-3H-imidazo[4,5-b]pyridine-5-methanol; N-[2-[3-chloro-5-[[2-ethyl-5-[2-(hydroxypropyl)]-7-methyl-3H-imidazo[4,5-b]pyridin-3-yl]methyl]-2-benzofuranyl]phenyl]trifluoromethanesulphonamide; 3-[[3-chloro-2-[2-[[(trifluoromethyl)sulphonyl]amino]phenyl]-5-benzofuranyl]methyl]-7-methyl-2-propyl-3H-imidazo[4,5-b]pyridine-5-methanol; N-[2-[3-chloro-5-[[5-[2-(hydroxypropyl)]-7-methyl-2-propyl-3H-imidazo[4,5-b]pyridin-3-yl]methyl]-2-benzofuranyl]phenyl]trifluoromethanesulphonamide; and physiologically acceptable salts and solvates thereof. The invention further relates to processes for their preparation, pharmaceutical compositions containing them, and to their use in medicine, particularly in the treatment of hypertension. L'invention concerne les composés: N-[2-[3-chloro-5-[(5,7-diméthyl-2-éthyl-3H-imidazo[4,5-b]pyridin-3-yl)méthyl]-2-benzofuranyl]phényl]trifluorométhanesulfonamide; 3-[[3-chloro-2-[2-[[(trifluorométhyl)sulfonyl]amino]phényl]-5-benzofuranyl]méthyl]-2-éthyl-7-méthyl-3H-imidazo[4,5-b]pyridine-5-méthanol; N-[2-[3-chloro-5-[[2-éthyl-5-[2-(hydroxypropyl)]-7-méthyl-3H-imidazo[4,5-b]pyridin-3-yl]méthyl]-2-benzofuranyl]phényl]trifluorométhanesulfonamide; 3-[[3-chloro-2-[2-[[(trifluorométhyl)sulfonyl]amino]phényl]-5-benzofuranyl]méthyl]-7-methyl-2-propyl-3H-imidazo[4,5-b]pyridine-5-méthanol; N-[2-[3-chloro-5-[[5-[2-(hydroxypropyl)]-7-méthyl-2-propyl-3H-imidazo[4,5-b]pyridin-3-yl]méthyl]-2-benzofuranyl]phényl]trifluorométhanesulfonamide. L'invention concerne également les sels et les solvates de ces dérivés acceptables sur le plan pharmaceutique, ainsi que leur préparation, les compositions pharmaceutiques les contenant et leur utilisation en médecine, en particulier dans le traitement de l'hypertension.