NOVEL FURO-COUMARINSULFONAMIDES AS PROTEIN KINASE C INHIBITORS

The present invention provides novel furo-coumarinsulfonamide derivatives having formula (I), wherein R1, R3, R4, R5 and R6 are independently H or lower alkyl; m, n and p are independently 2, 3, 4, 5 or 6; A is NR4(CH2)pNR5, NR6, O or S; R2 is independently H, lower alkyl or a moiety of formula (a)...

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Bibliographic Details
Main Authors JIANG, JACK, B, JOHNSON, MARY, GEORGE
Format Patent
LanguageEnglish
French
Published 11.05.1994
Edition5
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention provides novel furo-coumarinsulfonamide derivatives having formula (I), wherein R1, R3, R4, R5 and R6 are independently H or lower alkyl; m, n and p are independently 2, 3, 4, 5 or 6; A is NR4(CH2)pNR5, NR6, O or S; R2 is independently H, lower alkyl or a moiety of formula (a) useful for inhibiting protein kinase C and treating conditions related to, or affected by inhibition of protein kinase C, particularly cancer tumors, inflammatory disease, reperfusion injury, and cardiac dysfunctions related to reperfusion injury. Nouveaux dérivés de furo-coumarinsulfonamides de la formule (I) dans laquelle R1, R3, R4, R5 et R6 sont indépendamment H ou alkyle inférieur; m, n et p sont indépendamment 2, 3, 4, 5 ou 6; A est NR4(CH2)pNR5, NR6, O ou S; R2 est indépendamment H, alkyle inférieur ou une fraction de la formule (a). Lesdits dérivés sont utiles pour inhiber la protéine kinase C et traiter des pathologies associées à l'inhibition de la protéine kinase C ou influencées par ladite inhibition, en particulier les tumeurs cancéreuses, les maladies inflammatoires, les lésions consécutives à la perfusion et les dysfonctionnements cardiaques liés aux lésions consécutives à la perfusion.
Bibliography:Application Number: WO1992US08998