BOVINE PANCREATIC TRYPSIN INHIBITOR DERIVED INHIBITORS OF FACTOR VIIA-TISSUE FACTOR COMPLEX

• Main Authors: LASTERS, IGNACE, DE MAEYERS, MARC, RIPKA, WILLIAM, CHARLES
• Format: Patent
• Language: English; French
• Published: 14.04.1994
• Edition: 5
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES USING MICROORGANISMS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

Compounds derived from BPTI which inhibit factor VIIa-TF complex with an inhibition constant of less than 500 nM, their pharmaceutical compositions, and methods of use. Also disclosed are isolated nucleic acid segments encoding for the compounds, vectors comprising the nucleic acid segment and promoter, transformed host cells, and a method for preparing the compounds using transformed host cells. Composés dérivés de l'inhibiteur de trypsine pancréatique de bovin (BPM), qui inhibent le complexe facteur VIIa-thromboplastine tissulaire selon une constante d'inhibition inférieure à 500 nm. Des compositions pharmaceutiques les contenant et des procédés d'utilisation sont également décrits, ainsi que des segments d'acide nucléique isolés codant ces composés, des vecteurs comprenant le segment d'acide nucléique, et une région promoteur des cellules hôtes transformées, et un procédé de préparation des composés consistant à utiliser les cellules hôtes transformées.