VASOACTIVE PEPTIDE INHIBITION

• Main Authors: BONE, ELISABETH, ANN, WOOD, LARS, MICHAEL, CRIMMIN, MICHAEL, JOHN
• Format: Patent
• Language: English; French
• Published: 14.04.1994
• Edition: 5
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Certain known hydroxamic acid derivatives and their salts are useful as inhibitors of the conversion of Big Endothelin to Endothelin by a putative endothelin converting enzyme, and are useful in the management of diseases mediated by overproduction of, or over-responsiveness to, endothelin in mammal...