IMPROVED IMPLANT MATERIALS, METHODS OF TREATING THE SURFACE OF IMPLANTS WITH MICROVASCULAR ENDOTHELIAL CELLS, AND THE TREATED IMPLANTS THEMSELVES

• Main Authors: WILLIAMS, STUART, K, JARRELL, BRUCE, E
• Format: Patent
• Language: English
• Published: 01.09.1994
• Edition: 5
• Subjects: BANDAGES, DRESSINGS OR ABSORBENT PADS; BEER; BIOCHEMISTRY; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; ENZYMOLOGY; FILTERS IMPLANTABLE INTO BLOOD VESSELS; FIRST-AID KITS; FOMENTATION; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; PROSTHESES; SPIRITS; TREATMENT OR PROTECTION OF EYES OR EARS; VINEGAR; WINE

Implant materials having porosity are provided by the present invention. Methods for treating a synthetic or naturally occurring implant, such as a vascular graft, intended for implantation in a human patient are also provided comprising obtaining human microvascular fat tissue, homogenizing the fat tissue to provide a cellular slurry, and applying the cellular slurry onto said implant to provide at least 50% confluence of said cells on the surface and/or within the pores of the implant.